Methodology & sources

Every evidence label answers one question and no other: how much human evidence exists for this compound, for this use? Not whether it is popular, not whether it is available, not whether it works in mice. Human evidence, or the absence of it.

The most common failure in this space is presenting rodent results as if they were clinical findings. We separate the two explicitly on every compound page. A compound can have hundreds of animal studies and still have no idea what it does in people.

We do not sell, supply, source, broker or recommend any compound. We do not accept payment for placement or grading. We do not publish dosing advice — where figures appear, they are quoted from a source document and labelled as such. No commercial relationship influences a single label on this site.

Assessments will be wrong sometimes. When new human evidence lands, labels change, and we say what changed and why. A grade that never moves is not a grade — it is an opinion in costume.

Primary sources only: peer-reviewed literature via PubMed and Europe PMC, trial registrations via ClinicalTrials.gov, and regulator publications from the SFDA, FDA and EMA. Vendor material is never a source. Per-compound citation lists are being added — pages awaiting that pass are marked.