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CJC-1295 (no DAC)

REC PPT-CJC-1295 // REV 2026-10-04 // assessment changes are logged, never silent

GHRH analogue, usually stacked with a secretagogue.

What it is

A synthetic analogue of growth-hormone-releasing hormone. The ‘no DAC’ version has a shorter duration than the DAC-modified form.

What it does

Acts on the GHRH receptor to amplify natural growth-hormone pulses, often combined with a ghrelin-receptor agonist.

Does it work?

Pharmacological effect on GH is documented. Clinical outcome data in healthy adults is limited, and long-term safety of sustained GH elevation is not well characterised.

Claims vs data

Each marketing claim, tagged by what the evidence actually supports.

Raises growth hormone and IGF-1 levels	supported
Builds muscle and burns fat in healthy adults	weak evidence
Long-term use is established as safe	overreach

Reference figures

Quoted from published reference material. These are not Peptuity recommendations.

Vial10 mg

Diluent3 ml

Listed dose200 mcg

Units / 1 ml6

Open in the calculator — prefilled →

The evidence, counted

Live counts from Europe PMC and ClinicalTrials.gov.

Publications 59

Randomised trials 2

Clinical trials 1

Registered studies 1

59 publications indexed, but only 2 randomised controlled trials and 1 registered interventional studies. Human evidence exists but is thin.

SRC // EUROPE PMC + CTGOV // "CJC-1295" // FETCHED 2026-10-04 // 59 RECORDS

Most-cited literature

[01] Signaling through the M(3) muscarinic receptor favors bone mass accrual by decreasing sympathetic activity
Shi Y, Oury F, Yadav VK, Wess J, Liu XS, Guo XE, Murshed M, Karsenty G · Cell Metab 2010 · 94 citations · DOI 10.1016/j.cmet.2010.01.005
[02] Immunoaffinity purification of peptide hormones prior to liquid chromatography-mass spectrometry in doping controls
Thomas A, Schänzer W, Delahaut P, Thevis M. · Methods 2012 · 75 citations · DOI 10.1016/j.ymeth.2011.08.009
[03] Transmembrane signal transduction by peptide hormones via family B G protein-coupled receptors
Culhane KJ, Liu Y, Cai Y, Yan EC. · Front Pharmacol 2015 · 58 citations · DOI 10.3389/fphar.2015.00264
[04] Identification of CJC-1295, a growth-hormone-releasing peptide, in an unknown pharmaceutical preparation
Henninge J, Pepaj M, Hullstein I, Hemmersbach P. · Drug Test Anal 2010 · 51 citations · DOI 10.1002/dta.233

Regulatory status

Formal, dated regulatory actions.

WADA — Prohibited List 2026

Prohibited in sport — WADA S2 (peptide hormones, growth factors and related substances)

source →

Common questions

What does no DAC mean?

DAC is a chemical modification that extends duration from hours to days. The no-DAC form acts briefly, preserving the natural pulsatile GH pattern.

Why is it stacked with ipamorelin?

They act on different receptors — GHRH and ghrelin — so the combination amplifies the same GH pulse from two directions. The stack itself has not been trialled.

Is sustained GH elevation safe?

Long-term safety in healthy adults is not well characterised. That absence of data is the honest answer.

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