home / compounds / CJC-1295 (no DAC)
CJC-1295 (no DAC)
GHRH analogue, usually stacked with a secretagogue.
What it is
A synthetic analogue of growth-hormone-releasing hormone. The ‘no DAC’ version has a shorter duration than the DAC-modified form.
What it does
Acts on the GHRH receptor to amplify natural growth-hormone pulses, often combined with a ghrelin-receptor agonist.
Does it work?
Pharmacological effect on GH is documented. Clinical outcome data in healthy adults is limited, and long-term safety of sustained GH elevation is not well characterised.
Claims vs data
Each marketing claim, tagged by what the evidence actually supports.
| Raises growth hormone and IGF-1 levels | supported |
| Builds muscle and burns fat in healthy adults | weak evidence |
| Long-term use is established as safe | overreach |
Reference figures
Quoted from published reference material. These are not Peptuity recommendations.
The evidence, counted
Live counts from Europe PMC and ClinicalTrials.gov.
54 publications indexed, but only 2 randomised controlled trials and 1 registered interventional studies. Human evidence exists but is thin.
query: "CJC-1295" · checked 2026-08-07
Most-cited literature
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Signaling through the M(3) muscarinic receptor favors bone mass accrual by decreasing sympathetic activity
Shi Y, Oury F, Yadav VK, Wess J, Liu XS, Guo XE, Murshed M, Karsenty G · Cell Metab 2010 · 89 citations
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Immunoaffinity purification of peptide hormones prior to liquid chromatography-mass spectrometry in doping controls
Thomas A, Schänzer W, Delahaut P, Thevis M. · Methods 2012 · 72 citations
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Transmembrane signal transduction by peptide hormones via family B G protein-coupled receptors
Culhane KJ, Liu Y, Cai Y, Yan EC. · Front Pharmacol 2015 · 56 citations
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Characteristics and Attitudes of Men Using Anabolic Androgenic Steroids (AAS): A Survey of 2385 Men
Bonnecaze AK, O'Connor T, Aloi JA. · Am J Mens Health 2020 · 50 citations
Regulatory status
Formal, dated regulatory actions.
WADA — Prohibited List 2026
Prohibited in sport — WADA S2 (peptide hormones, growth factors and related substances)
Common questions
What does no DAC mean?
DAC is a chemical modification that extends duration from hours to days. The no-DAC form acts briefly, preserving the natural pulsatile GH pattern.
Why is it stacked with ipamorelin?
They act on different receptors — GHRH and ghrelin — so the combination amplifies the same GH pulse from two directions. The stack itself has not been trialled.
Is sustained GH elevation safe?
Long-term safety in healthy adults is not well characterised. That absence of data is the honest answer.
Related compounds
Ipamorelin
Selective growth-hormone secretagogue. Raises GH; downstream benefits less proven.
Sermorelin
GHRH fragment with a long clinical history, once used diagnostically.
Tesamorelin
Approved GHRH analogue for HIV-associated lipodystrophy — a narrow, real indication.