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Triple Threat blend
REC PPT-TRIPLE-THREAT // REV 2026-10-04 // assessment changes are logged, never silent
NAD+, MOTS-c and 5-Amino-1MQ combined. Three unproven items in one vial.
What it is
A vendor blend combining a coenzyme, a mitochondrial peptide and a small-molecule enzyme inhibitor.
What it does
Marketed around metabolic and energy claims drawn from each component’s proposed mechanism.
Does it work?
None of the three has strong controlled human evidence for these uses, and the combination has none at all. This is the least evidence-supported item in the chart.
Claims vs data
Each marketing claim, tagged by what the evidence actually supports.
| Boosts energy and metabolism | weak evidence |
| Each component is clinically proven | overreach |
Reference figures
Quoted from published reference material. These are not Peptuity recommendations.
The evidence, counted
Live counts from Europe PMC and ClinicalTrials.gov.
790 publications indexed, but only 7 randomised controlled trials and 5 registered interventional studies. Human evidence exists but is thin.
SRC // EUROPE PMC + CTGOV // "MOTS-c" // FETCHED 2026-10-04 // 790 RECORDS
Most-cited literature
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[01]
Lipid Peroxidation and Iron Metabolism: Two Corner Stones in the Homeostasis Control of Ferroptosis
Rochette L, Dogon G, Rigal E, Zeller M, Cottin Y, Vergely C. · Int J Mol Sci 2022 · 776 citations · DOI 10.3390/ijms24010449
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[02]
The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance
Lee C, Zeng J, Drew BG, Sallam T, Martin-Montalvo A, Wan J, Kim SJ, Me · Cell Metab 2015 · 584 citations · DOI 10.1016/j.cmet.2015.02.009
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[03]
Mitochondrial signal transduction
Picard M, Shirihai OS. · Cell Metab 2022 · 524 citations · DOI 10.1016/j.cmet.2022.10.008
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[04]
Targeting fibrosis, mechanisms and cilinical trials
Zhao M, Wang L, Wang M, Zhou S, Lu Y, Cui H, Racanelli AC, Zhang L, Ye · Signal Transduct Target Ther 2022 · 460 citations · DOI 10.1038/s41392-022-01070-3
Regulatory status
Formal, dated regulatory actions.
WADA — Prohibited List 2026
Blend of components that are individually prohibited in sport (WADA)
Common questions
What are the three components?
NAD+ (a coenzyme), MOTS-c (a mitochondrial peptide) and 5-Amino-1MQ (a small-molecule enzyme inhibitor) — three different molecule classes in one vial.
Why do you call it the least-evidenced item?
None of the three has strong controlled human evidence for these uses, and the combination has none at all. Multiplying weak evidence does not add up to strong evidence.
Is the energy claim measurable?
Subjective energy is the easiest outcome to feel and the hardest to attribute. Without controlled comparison, reports of feeling better cannot be assigned to the vial.