Selank
REC PPT-SELANK // REV 2026-10-04 // assessment changes are logged, never silent
Anxiolytic peptide from the same Russian research lineage as Semax.
What it is
A synthetic analogue of the immunomodulatory peptide tuftsin.
What it does
Studied for anxiolytic effects, proposed to act via GABAergic and monoamine pathways without sedation.
Does it work?
Same situation as Semax: a genuine Russian clinical literature with limited independent international replication.
Claims vs data
Each marketing claim, tagged by what the evidence actually supports.
| Anxiolytic effect reported in Russian clinical studies | partially true |
| A non-sedating replacement for prescribed treatment | weak evidence |
Reference figures
Quoted from published reference material. These are not Peptuity recommendations.
molecular data — PubChem CID 11765600
The evidence, counted
Live counts from Europe PMC and ClinicalTrials.gov.
82 publications indexed, but only 2 randomised controlled trials and 9 registered interventional studies. Human evidence exists but is thin.
SRC // EUROPE PMC + CTGOV // "Selank" // FETCHED 2026-10-04 // 82 RECORDS
Most-cited literature
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[01]
When an obscurity becomes trend: social-media descriptions of tianeptine use and associated atypical drug use
Smith KE, Rogers JM, Strickland JC, Epstein DH. · Am J Drug Alcohol Abuse 2021 · 37 citations · DOI 10.1080/00952990.2021.1904408
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[02]
Tuftsin - Properties and Analogs
Siebert A, Gensicka-Kowalewska M, Cholewinski G, Dzierzbicka K. · Curr Med Chem 2017 · 37 citations · DOI 10.2174/0929867324666170725140826
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[03]
Screening of 109 neuropeptides on ASICs reveals no direct agonists and dynorphin A, YFMRFamide and endomorphin-1 as modulators
Vyvers A, Schmidt A, Wiemuth D, Gründer S. · Sci Rep 2018 · 23 citations · DOI 10.1038/s41598-018-36125-5
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[04]
Natural and hybrid ("chimeric") stable regulatory glyproline peptides
Ashmarin IP, Samonina GE, Lyapina LA, Kamenskii AA, Levitskaya NG, Gri · Pathophysiology 2005 · 20 citations · DOI 10.1016/j.pathophys.2004.10.001
Common questions
How is Selank related to Semax?
Same research lineage, different parent molecule — Selank derives from the immune peptide tuftsin and is studied mainly for anxiety rather than cognition.
Does it sedate like benzodiazepines?
The Russian literature reports anxiolytic effects without sedation or dependence. Those reports have limited independent replication.
Should it replace prescribed treatment for anxiety?
No. Anxiety disorders have evidence-based treatments; an under-replicated research peptide is not among them.