DSIP
Delta sleep-inducing peptide — named for an effect that has not replicated well.
What it is
A nonapeptide first isolated from rabbit brain during sleep research in the 1970s.
What it does
Named for observed delta-wave sleep effects in early animal work; the mechanism remains poorly defined.
Does it work?
Despite the evocative name, human sleep evidence is inconsistent and the compound has not progressed to established clinical use in five decades — that longevity without adoption is itself informative.
Claims vs data
Each marketing claim, tagged by what the evidence actually supports.
| Induces delta-wave sleep | weak evidence |
| Human sleep findings are consistent | overreach |
Reference figures
Quoted from published reference material. These are not Peptuity recommendations.
The evidence, counted
Live counts from Europe PMC and ClinicalTrials.gov.
499 publications indexed, but only 6 randomised controlled trials and 0 registered interventional studies. Human evidence exists but is thin.
query: "DSIP" · checked 2026-08-07
Most-cited literature
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Molecular biology of the blood-brain and the blood-cerebrospinal fluid barriers: similarities and differences
Redzic Z. · Fluids Barriers CNS 2011 · 264 citations
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Deamidation and isoaspartate formation in proteins: unwanted alterations or surreptitious signals?
Reissner KJ, Aswad DW. · Cell Mol Life Sci 2003 · 218 citations
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GA4GH: International policies and standards for data sharing across genomic research and healthcare
Rehm HL, Page AJH, Smith L, Adams JB, Alterovitz G, Babb LJ, Barkley M · Cell Genom 2021 · 217 citations
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Biochemical regulation of non-rapid-eye-movement sleep
Obal F, Krueger JM. · Front Biosci 2003 · 204 citations
Regulatory status
Formal, dated regulatory actions.
WADA — Prohibited List 2026
Prohibited in sport — WADA S0 (substance without any health-authority approval)
US FDA — 503A compounding 2026-07
Advisory committee (PCAC) voted 6–7 against inclusion on the 503A compounding list in July 2026 — the only peptide rejected at that meeting.
Common questions
Does DSIP actually induce sleep?
The name records an effect observed in early animal work. Five decades later, human findings remain inconsistent and the mechanism undefined.
Why is fifty years without adoption informative?
A genuinely effective sleep compound discovered in the 1970s would have been developed. Longevity without clinical adoption is evidence in itself.
What has better evidence for sleep?
Behavioural treatment of insomnia and clinician-guided options. Sleep is one area where evidence-based alternatives are genuinely available.
Why was DSIP rejected by the FDA compounding committee?
At the July 2026 PCAC meeting it was the only peptide voted down (6–7) for the 503A compounding list. The committee did not find its evidence base sufficient — consistent with the five-decades-without-adoption picture on this page.