SS-31
15 RCTsEmerging
| Supports mitochondrial structure and function | preclinical only |
| Trialled in humans for mitochondrial disease | supported |
| Delivers anti-ageing benefits in healthy people | weak evidence |
Goal matrix
Longevity
Every compound we track for this goal.
4 Emerging4 Limited evidence
01
The matrix
Humanin
14 RCTsEmerging
| Circulating levels have been associated with cognitive ageing in human cohorts | supported |
| The analogue HNG extends lifespan and healthspan in laboratory organisms | preclinical only |
| Higher humanin means better mitochondrial health in any given person | weak evidence |
| Injecting humanin slows human ageing or extends human lifespan | overreach |
CJC-1295 (no DAC)
2 RCTsEmerging
| Raises growth hormone and IGF-1 levels | supported |
| Builds muscle and burns fat in healthy adults | weak evidence |
| Long-term use is established as safe | overreach |
NAD+
2 RCTsEmerging
| Oral precursors raise NAD+ levels | supported |
| Slows human ageing | weak evidence |
| IV NAD+ is better studied than oral precursors | overreach |
Thymalin / Thymogen
2 RCTsLimited evidence
| Restores immune parameters in the elderly | weak evidence |
| Findings replicated by independent international groups | overreach |
PNC-27
1 RCTsLimited evidence
| Binds HDM-2 and forms membrane pores in cancer cell lines in vitro | preclinical only |
| Reduces tumour size in mouse xenograft models | animal data only |
| Kills cancer cells only and leaves normal cells untouched | weak evidence |
| A selective cancer treatment for people | overreach |
Epitalon
0 RCTsLimited evidence
| Extends human lifespan | overreach |
| Activates telomerase | weak evidence |
FOXO4-DRI
0 RCTsLimited evidence
| Cleared senescent cells in aged mice | animal data only |
| A proven senolytic for human use | overreach |
02